British Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation on an underground arms cache in Syrian territory used by the IS group, as stated by the British defence ministry.
The facility, identified by intelligence, was thought to be housing weapons and explosive materials, the release indicated, and was positioned in mountains just to the north of Palmyra in Syria's central region.
"Our fighter planes employed Paveway IV guided bombs to target a several entry passages leading to the depot... early reports indicate the strike was effective," officials stated.
There was no sign of any harm to civilians in the attack late on Saturday and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
IS - also known as Daesh - imposed extremist governance over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This operation underscores the UK's leading role, and commitment to operate in unison with our allies, to stamp out any re-emergence of Daesh and their dangerous and violent ideologies in the area," UK Defence Secretary the Defence Secretary remarked.
RAF aircraft have performed patrols over Syrian airspace to "deter any attempted resurgence" of Islamic State following its defeat at the Baghuz confrontation in 2019, the MoD reported.
"I want to thank the personnel of our armed forces involved in this strike for their expertise and their courage," the Defence Secretary added. "Including them were a great many UK service members stationed over the holidays. This operation, to eliminate militants who pose a risk to our way of life, shows how our armed forces are always on standby, continuously, protecting the UK within its borders and powerful internationally."
Last December, the American forces carried out what it described as a "massive strike" against IS targets in the country, following an ambush resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The UN estimates Daesh still maintains between 5,000 and 7,000 fighters in Syria and Iraq.